HCID 86662717, compound → 1-[3-cyclopropyl-1-(4-methoxyphenyl)-1H-pyrazol-4-yl]-3-methylbutan-1-ol

HRID 2090895Notes

Reaction equation

HRID 2090895 reaction equation
[CH:1]1([C:4]2[C:8]([CH:9]=[O:10])=[CH:7][N:6]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=3)[N:5]=2)[CH2:3][CH2:2]1.[CH2:19]([Mg]Br)[CH:20]([CH3:22])[CH3:21]>O1CCCC1>[CH:1]1([C:4]2[C:8]([CH:9]([OH:10])[CH2:19][CH:20]([CH3:22])[CH3:21])=[CH:7][N:6]([C:11]3[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=3)[N:5]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 86662717HCID 86662717, compoundHCID 178418816HCID 178418816, compound

Product 1

HCID 667772971-[3-cyclopropyl-1-(4-methoxyphenyl)-1H-pyrazol-4-yl]-3-methylbutan-1-olYield 82%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Cyclopropyl-1-(4-methoxyphenyl)-1H-pyrazole-4-carbaldehyde (1.8 g) synthesized above was dissolved in tetrahydrofuran (10 mL), isobutylmagnesium bromide (1M tetrahydrofuran solution, 12 mL) was added dropwise at 0° C. In the same manner as in Example 1(6), the title object compound (1.8 g, 82%) was obtained as a white solid.

Sources & evidence

ORD record
ord-78214c40dcf1474b870d5f0fdc68d3a8
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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