Bicarbonate Ion → 1-(2,2-Difluoroethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine
Reaction equation
[Br:23][CH2:24][CH:25]([F:26])[F:27].[C:30](=[O:31])([O-:32])[O-:33].[CH3:1][C:2]1([CH3:22])[CH2:3][CH:4]([c:10]2[c:11]([N:16]3[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]3)[cH:12][cH:13][cH:14][cH:15]2)[CH2:5][C:6]([CH3:8])([CH3:9])[CH2:7]1.[CH3:41][CH2:42][O:43][CH2:44][CH3:45].[CH3:46][N:47]([CH3:48])[CH:49]=[O:50].[I-:29].[K+:34].[K+:35].[Na+:28].[Na+:36].[OH:37][C:38](=[O:39])[O-:40]>>[CH3:1][C:2]1([CH3:22])[CH2:3][CH:4]([c:10]2[c:11]([N:16]3[CH2:17][CH2:18][N:19]([CH2:24][CH:25]([F:26])[F:27])[CH2:20][CH2:21]3)[cH:12][cH:13][cH:14][cH:15]2)[CH2:5][C:6]([CH3:8])([CH3:9])[CH2:7]1Participants
10
Reactant 9
Product 1
Sources & evidence
- ORD record
- ord-36c9361fe03343e6888c34f4087f398c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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