Trifluoroacetic acid → HCID 68431410, compound

HRID 2092074Notes

Reaction equation

HRID 2092074 reaction equation
[Br:1][C:2]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([NH:12][CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])=[O:11])[N:5]=[CH:4][C:3]=1[NH:21][C@@H:22]1[CH2:27][C@@H:26]2[CH2:28][C@@H:24]([C:25]2([CH3:30])[CH3:29])[C@H:23]1[CH3:31].FC(F)(F)C(O)=O>ClCCl>[Br:1][C:2]1[C:7](=[O:8])[N:6]([CH2:9][C:10]([NH:12][CH2:13][C:14]([OH:16])=[O:15])=[O:11])[N:5]=[CH:4][C:3]=1[NH:21][C@@H:22]1[CH2:27][C@@H:26]2[CH2:28][C@@H:24]([C:25]2([CH3:30])[CH3:29])[C@H:23]1[CH3:31]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70830876HCID 70830876, compound

Product 1

HCID 68431410HCID 68431410, compoundYield 94.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 2-(2-{5-bromo-6-oxo-4-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-ylamino]pyridazin-1(6H)-yl}acetamido)acetate (18 mg, 0.036 mmol) prepared in Synthetic Example 10 in dichloromethane (1 mL) was stirred with trifluoroacetic acid (0.1 mL) at room temperature. After completion of the reaction, the reaction solution was concentrated to give the desired product (15 mg, 94% yield).

Workup

  1. customAfter completion of the reaction
  2. concentrationthe reaction solution was concentrated

Sources & evidence

ORD record
ord-8989a528be5a40a7baf225b37e885560
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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