Hydrochloric Acid → HCID 25154342, compound

HRID 2092189Notes

Reaction equation

HRID 2092189 reaction equation
[C:1]1([S:7]([C:10]2[CH:11]=[N:12][C:13]3[C:18]([CH:19]=2)=[CH:17][CH:16]=[CH:15][C:14]=3[N:20]2[CH2:24][CH:23]3[CH2:25][CH2:26][N:27](C(OC(C)(C)C)=O)[CH:22]3[CH2:21]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:35]>C(Cl)Cl>[ClH:35].[NH:27]1[CH2:26][CH2:25][CH:23]2[CH2:24][N:20]([C:14]3[CH:15]=[CH:16][CH:17]=[C:18]4[C:13]=3[N:12]=[CH:11][C:10]([S:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)(=[O:9])=[O:8])=[CH:19]4)[CH2:21][CH:22]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 44474551HCID 44474551, compound

Product 1

HCID 25154342HCID 25154342, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
50 °C

Procedure

A solution of tert-butyl 5-(3-(phenylsulfonyl)quinolin-8-yl)hexahydropyrrolo[2,3-c]pyrrole-1(2H)-carboxylate (92 mg, 0.19 mmol) in CH2Cl2 (5 ml) was treated with hydrochloric acid (4M in dioxane, 2 ml) at 0° C. and then stirred at 50° C. for 16 h. After concentration, the product was washed with EtOAc and dried in vacuo to give the title compound (80 mg, 100% as a white solid.

Workup

  1. concentrationAfter concentration
  2. washthe product was washed with EtOAc
  3. customdried in vacuo

Sources & evidence

ORD record
ord-cd215cd387f24de4966cd963410d407f
Source dataset
uspto-grants-2013_05
Patent number
US08440694B2

Reaction notes

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