Hydrochloric Acid → HCID 68728360, compound

HRID 2092205Notes

Reaction equation

HRID 2092205 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:12]=[N:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][C:15]=3I)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[Cl-:22].C(OC([N:30]1[CH:34]2[CH2:35][NH2+:36][CH2:37][CH:33]2[CH2:32][CH2:31]1)=O)(C)(C)C.Cl>>[Cl-:22].[F:1][C:2]1[CH:3]=[C:4]([S:8]([C:11]2[CH:12]=[N:13][C:14]3[C:19]([CH:20]=2)=[CH:18][CH:17]=[CH:16][C:15]=3[N:36]2[CH2:37][CH:33]3[CH:34]([NH2+:30][CH2:31][CH2:32]3)[CH2:35]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 673141573-(3-Fluorophenylsulfonyl)-8-iodoquinolineHCID 68725523HCID 68725523, compound

Product 1

HCID 68728360HCID 68728360, compound

Procedure

0.088 g of 5-(3-(3-fluorophenylsulfonyl)quinolin-8-yl)octahydropyrrolo[3,4-b]pyrrol-1-ium chloride were prepared by analogy to the methods of Examples 27 and 28 by coupling of 3-(3-fluorophenylsulfonyl)-8-iodoquinoline with 1-(tert-butoxycarbonyl)-octahydropyrrolo[2,3-c]pyrrol-5-ium chloride and subsequent deprotection of the tert-butyl-oxycarbonyl derivative with HCl in isoproanol.

Sources & evidence

ORD record
ord-627b580c31f84f6dabb14a181ca24166
Source dataset
uspto-grants-2013_05
Patent number
US08440694B2

Reaction notes

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