Hydrochloric Acid → HCID 46240204, compound

HRID 2092434Notes

Reaction equation

HRID 2092434 reaction equation
[OH-].[Li+].C([O:5][C:6](=[O:40])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[O:24][N:23]=[C:22]([CH3:25])[C:21]=3[NH:26][C:27]([O:29][CH:30]([C:32]3[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][C:33]=3[F:39])[CH3:31])=[O:28])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)C.Cl>CO.O>[Cl:38][C:35]1[CH:36]=[CH:37][C:32]([CH:30]([O:29][C:27]([NH:26][C:21]2[C:22]([CH3:25])=[N:23][O:24][C:20]=2[C:17]2[CH:18]=[CH:19][C:14]([C:11]3[CH:12]=[CH:13][C:8]([CH2:7][C:6]([OH:40])=[O:5])=[CH:9][CH:10]=3)=[CH:15][CH:16]=2)=[O:28])[CH3:31])=[C:33]([F:39])[CH:34]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 67350795HCID 67350795, compound

Product 1

HCID 46240204HCID 46240204, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Excess lithium hydroxide was added to a solution of (4′-{4-[1-(4-chloro-2-fluoro-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid ethyl ester (0.100 g, 0.19 mmol) in methanol and water, and the reaction was stirred at room temperature overnight. The mixture was acidified with 1N aqueous HCl and extracted with EtOAc, and the combined organic layers were dried, filtered, and concentrated. The residue was purified by preparative HPLC to give the title compound.

Workup

  1. extractionextracted with EtOAc
  2. customthe combined organic layers were dried
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe residue was purified by preparative HPLC

Sources & evidence

ORD record
ord-d6c736b6c6dc4b0aa6fed30c418c0047
Source dataset
uspto-grants-2013_05
Patent number
US08440707B2

Reaction notes

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