N-methylhydroxylamine hydrochloride → HCID 24959566, compound

HRID 2092501Notes

Reaction equation

HRID 2092501 reaction equation
[F:1][C@:2]([C:7]1[CH:12]=[CH:11][C:10]([O:13][S:14]([C:17]([F:20])([F:19])[F:18])(=[O:16])=[O:15])=[CH:9][CH:8]=1)([CH3:6])[C:3](O)=[O:4].Cl.[CH3:22][NH:23][OH:24]>>[F:18][C:17]([F:20])([F:19])[S:14]([O:13][C:10]1[CH:11]=[CH:12][C:7]([C@@:2]([F:1])([CH3:6])[C:3]([N:23]([OH:24])[CH3:22])=[O:4])=[CH:8][CH:9]=1)(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 77906N-methylhydroxylamine hydrochlorideHCID 24959563HCID 24959563, compound

Product 1

HCID 24959566HCID 24959566, compound

Procedure

Following the same procedure described for 4 and starting from 2 (1.6 mmol) and N-methylhydroxylamine hydrochloride (2 mmol), after workup compound 5 was isolated as a colourless oil (0.34 g, yield 63%). [α]D=+10.5 (c=0.5; CH3OH). 1H-NMR (CDCl3) δ 7.65 (d, 2H, J=7 Hz), 7.30 (d, 2H, J=7 Hz), 2.90 (s, 3H), 1.94 (d, 3H, J=23 Hz).

Sources & evidence

ORD record
ord-07c74c6af8c04b0283e0e06e05cfca71
Source dataset
uspto-grants-2013_05
Patent number
US08440711B2

Reaction notes

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