Hydrochloric Acid → HCID 51038883, compound

HRID 2092642Notes

Reaction equation

HRID 2092642 reaction equation
C(OC(=O)[NH:7][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH:11]3[C:18]#[N:19])[CH2:9]1)[CH2:15]2)(C)(C)C.Cl>O1CCOCC1>[NH2:7][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH:11]3[C:18]#[N:19])[CH2:9]1)[CH2:15]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58192769HCID 58192769, compound

Product 1

HCID 51038883HCID 51038883, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 7C (30 mg, 0.10 mmol) in 2 mL of 1,4-dioxane was added HCl (4N in 1,4-dioxane, 1.0 mL). The mixture was stirred at rt for overnight. The solvent was removed under vacuum. The resulting residue was dissolved in 2 mL of water and was washed with EtOAc (5 mL×3). The water was the removed under vacuum to give the title compound as hydrogen chloride salts (7) respectively (20 mg). LC-MS (ESR): m/z=177 (M+H)+

Workup

  1. customThe solvent was removed under vacuum
  2. dissolutionThe resulting residue was dissolved in 2 mL of water
  3. washwas washed with EtOAc (5 mL×3)
  4. customremoved under vacuum

Sources & evidence

ORD record
ord-84585dac64404116ace2b688573244f5
Source dataset
uspto-grants-2013_05
Patent number
US08440720B2

Reaction notes

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