Hydrochloric Acid → Hydrochloric Acid

HRID 2092648Notes

Reaction equation

HRID 2092648 reaction equation
C(OC(=O)[NH:7][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([C:11]3=[N:18][OH:19])[CH2:9]1)[CH2:15]2)(C)(C)C.[ClH:21]>O1CCOCC1>[NH2:7][C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([C:11]3=[N:18][OH:19])[CH2:9]1)[CH2:15]2.[ClH:21]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58192797HCID 58192797, compound

Product 2

HCID 313Hydrochloric AcidHCID 51038896HCID 51038896, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of oxime 14A (0.17 mmol) in 1,4-dioxane (2.0 mL) was diluted with a solution of 4 N HCl in dioxane (1.0 mL) and the reaction mixture was maintained at rt for 16 h. The reaction mixture was concentrated and dried to provide amine 14 in 88% yield as a hydrochloric acid salt. Data: LC/MS (ESR) m/z=195 [M+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customdried

Sources & evidence

ORD record
ord-e5bc3f123fe1406e8a4dd0ff71bed34a
Source dataset
uspto-grants-2013_05
Patent number
US08440720B2

Reaction notes

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