Hydrochloric Acid → 2-(4-((R)-2,2,2-trifluoro-1-hydroxy-ethyl)phenyl)-2-aza-spiro[4.5]decane-1,8-dione

HRID 2092677Notes

Reaction equation

HRID 2092677 reaction equation
[F:1][C:2]([F:27])([F:26])[C@@H:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:24][CH2:23][C:13]3([CH2:22][CH2:21][C:16]4(OCC[O:17]4)[CH2:15][CH2:14]3)[C:12]2=[O:25])=[CH:7][CH:6]=1)[OH:4].Cl>C1COCC1>[F:27][C:2]([F:1])([F:26])[C@@H:3]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:24][CH2:23][C:13]3([CH2:14][CH2:15][C:16](=[O:17])[CH2:21][CH2:22]3)[C:12]2=[O:25])=[CH:7][CH:6]=1)[OH:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 5823010310-[(R)-4-(2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one

Product 1

HCID 582300452-(4-((R)-2,2,2-trifluoro-1-hydroxy-ethyl)phenyl)-2-aza-spiro[4.5]decane-1,8-dione

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared in analogy to example 133, step 5 from 10-[4-((R)-2,2,2-trifluoro-1-hydroxy-ethyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one (4.09 g) by treatment with 2 M HCl (64 ml) in THF (127 ml) as a white solid. (4.06 g). MS (m/e): 342.130 [MH+].

Sources & evidence

ORD record
ord-e0cd2a767fdc43ba845508fb574627f9
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

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