Hydrochloric Acid → HCID 66580404, compound

HRID 2092708Notes

Reaction equation

HRID 2092708 reaction equation
[F:1][C:2]1([F:27])[CH2:5][CH:4]([C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:25][CH2:24][C:14]4([CH2:23][CH2:22][C:17]5(OCC[O:18]5)[CH2:16][CH2:15]4)[C:13]3=[O:26])=[CH:8][CH:7]=2)[CH2:3]1.Cl.CCOC(C)=O>CCCCCCC>[F:27][C:2]1([F:1])[CH2:3][CH:4]([C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:25][CH2:24][C:14]4([CH2:15][CH2:16][C:17](=[O:18])[CH2:22][CH2:23]4)[C:13]3=[O:26])=[CH:8][CH:7]=2)[CH2:5]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 66580350HCID 66580350, compound

Product 1

HCID 66580404HCID 66580404, compound

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

The title compound was prepared in analogy to example 133 step 5 from 10-[4-(3,3-Difluoro-cyclobutyl)-phenyl]-1,4-dioxa-10-aza-dispiro[4.2.4.2]tetradecan-9-one (described in example 340, step 2) by treatment with 2M HCl. White solid (89%). Rf 0.53 (4:1 AcOEt:heptane)

Sources & evidence

ORD record
ord-fa57657b679047aab25cddbd6e040ea8
Source dataset
uspto-grants-2013_05
Patent number
US08440710B2

Reaction notes

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