反应详情

A mixture of 3-(4-Chloro-benzyl)-3-methyl-2,3-dihydro-benzofuran-6-carboxylic acid methyl ester (100 mg, 0.32 mmol), sodium hydroxide (100 mg, 2.5 mmol), ethanol (3 ml) and water (0.5 ml) in tetrahydrofuran (4 ml), was stirred for 12 h at room temperature. The reaction medium was acidified by adding a 1.2 M hydrochloric acid solution and extracted with ethyl acetate. The organic phase was washed with water, dried (Na2SO4), and concentrated in a rotary evaporator. The product was obtained as a white solid. (M: 89 mg, 92%).

1. extractionextracted with ethyl acetate
2. washThe organic phase was washed with water
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated in a rotary evaporator
5. customThe product was obtained as a white solid