Lithium Hydroxide → (Benzo[1,3]dioxol-5-ylamino)-acetic acid

HRID 2093113Notes

Reaction equation

HRID 2093113 reaction equation
C([O:3][C:4](=[O:16])[CH2:5][NH:6][C:7]1[CH:15]=[CH:14][C:10]2[O:11][CH2:12][O:13][C:9]=2[CH:8]=1)C.[OH-].[Li+]>CO>[O:11]1[C:10]2[CH:14]=[CH:15][C:7]([NH:6][CH2:5][C:4]([OH:16])=[O:3])=[CH:8][C:9]=2[O:13][CH2:12]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 745625Ethyl 2-(1,3-benzodioxol-5-ylamino)acetate

Product 1

HCID 5229860(Benzo[1,3]dioxol-5-ylamino)-acetic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of compound (Benzo[1,3]dioxol-5-ylamino)-acetic acid ethyl ester in methanol was added lithium hydroxide (1.2 eq.) and stirred for overnight. Reaction mixture was then concentrated and neutralized to afford (Benzo[1,3]dioxol-5-ylamino)-acetic acid.

Workup

  1. customReaction mixture
  2. concentrationwas then concentrated

Sources & evidence

ORD record
ord-f9055fe229f94d2cb1be45b8718fc4a9
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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