p-Toluenesulfonic acid → HCID 86650193, compound

HRID 2093115Notes

Reaction equation

HRID 2093115 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([C:11]1[S:12][C:13]2[CH2:14][N:15]([C:20]([NH:22][C:23]3[CH:24]=[N:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=3)=[O:21])[CH2:16][CH2:17][C:18]=2[N:19]=1)=[O:10].[C:31]1([CH3:41])[CH:36]=[CH:35][C:34](S(O)(=O)=O)=[CH:33][CH:32]=1>O1CCCC1>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([C:11]1[S:12][C:13]2[CH2:14][N:15]([C:20]([NH:22][C:23]3[CH:24]=[N:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=3)=[O:21])[CH2:16][CH2:17][C:18]=2[N:19]=1)=[O:10].[CH3:41][C:31]1[CH:36]=[CH:35][C:34]([NH2:1])=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 25230966HCID 25230966, compound

Product 1

HCID 86650193HCID 86650193, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of N2-(2-aminophenyl)-N5-(6-methoxypyridin-3-yl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide obtained in example 38 in tetrahydrofuran at 0° C. was added toluene-4-sulfonic acid (1.2 eq.) and stirred at room temperature for 3-4 hrs. White precipitated solid was filtered out and dried to afford title compound.

Workup

  1. customWhite precipitated solid
  2. filtrationwas filtered out
  3. customdried

Sources & evidence

ORD record
ord-d69f0d7d45e747109aed180e954e1675
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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