Methanesulfonic Acid → HCID 86650194, compound

HRID 2093116Notes

Reaction equation

HRID 2093116 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([C:11]1[S:12][C:13]2[CH2:14][N:15]([C:20](=[O:31])[CH2:21][O:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([O:29][CH3:30])[CH:24]=3)[CH2:16][CH2:17][C:18]=2[N:19]=1)=[O:10].[CH3:32][S:33]([OH:36])(=[O:35])=[O:34]>O1CCCC1>[CH3:32][S:33]([OH:36])(=[O:35])=[O:34].[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([C:11]1[S:12][C:13]2[CH2:14][N:15]([C:20](=[O:31])[CH2:21][O:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([O:29][CH3:30])[CH:24]=3)[CH2:16][CH2:17][C:18]=2[N:19]=1)=[O:10]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 66864296HCID 66864296, compound

Product 1

HCID 86650194HCID 86650194, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of N-(2-aminophenyl)-5-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetrahydro[1,3]-thiazolo[5,4-c]pyridine-2-carboxamide obtained in example 179 in tetrahydrofuran at 0° C. was added methane sulfonic acid (1.2 eq.) and stirred at room temperature for 3-4 hrs. White precipitated solid was filtered out and dried to afford title compound.

Workup

  1. customWhite precipitated solid
  2. filtrationwas filtered out
  3. customdried

Sources & evidence

ORD record
ord-16a861fdb1034b8e80d7dc617ca66b68
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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