Tert-butyl 1'-(5-methylpyrazin-2-yl)-4,4'-bipiperidine-1-carboxylate → 1-(5-Methylpyrazin-2-yl)-4,4'-bipiperidine

HRID 2093479Notes

Reaction equation

HRID 2093479 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([CH:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1>FC(F)(F)C(O)=O>[CH3:1][C:2]1[N:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:10][CH2:9]2)=[N:6][CH:7]=1

Participants

3

Reactant 1

HCID 59178865Tert-butyl 1'-(5-methylpyrazin-2-yl)-4,4'-bipiperidine-1-carboxylate

Product 1

HCID 591788971-(5-Methylpyrazin-2-yl)-4,4'-bipiperidine

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The tert-butyl 1′-(5-methylpyrazin-2-yl)-4,4′-bipiperidine-1-carboxylate (1 g, 2.8 mmol) was dissolved in trifluoroacetic acid and stirred at r.t. for 5 minutes. The solution was concentrated in vac. The residue was dissolved in toluene (10 mL) and concentrated in vac.(×2) to yield the title compound.

Workup

  1. concentrationThe solution was concentrated in vac
  2. dissolutionThe residue was dissolved in toluene (10 mL)
  3. concentrationconcentrated in vac.(×2)

Sources & evidence

ORD record
ord-3a168a2289824881a11ed7126910e5c9
Source dataset
uspto-grants-2013_05
Patent number
US08445499B2

Reaction notes

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