1,1-Dimethoxyethyl(dimethyl)amine → HCID 67170049, compound

HRID 2093782Notes

Reaction equation

HRID 2093782 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([CH3:11])=[CH:4][C:3]=1[C:12](=[O:14])[CH3:13].CO[C:17](OC)([N:19]([CH3:21])[CH3:20])[CH3:18]>>[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([CH3:11])=[CH:4][C:3]=1[C:12](=[O:14])[CH:13]=[C:17]([N:19]([CH3:21])[CH3:20])[CH3:18]

Participants

3

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 67167386HCID 67167386, compound

Product 1

HCID 67170049HCID 67170049, compound

Conditions

Temperature
130 °C

Procedure

A mixture of 1-(2,5-dimethyl-4-nitrophenyl)ethanone (Step 1, 300 mg, 1.55 mmol) and 1,1-dimethoxy-N,N-dimethylethanamine (1 mL) was heated in a microwave at 130° C. for 10 min. The crude product was purified with silica gel chromatography (60% ethyl acetate in hexanes) to afford 1-(2,5-dimethyl-4-nitrophenyl)-3-(dimethylamino)but-2-en-1-one as a yellow solid.

Workup

  1. customThe crude product was purified with silica gel chromatography (60% ethyl acetate in hexanes)

Sources & evidence

ORD record
ord-72c1c666286c404f9933267fba376ea7
Source dataset
uspto-grants-2013_05
Patent number
US08445505B2

Reaction notes

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