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HRID20940

反应详情

EQUATION

反应方程式

HRID 20940 的结构方程式

REACTANTS

反应物

5
结构：CCCNCCC
HCID8902

Dipropylamine

C6H15N

结构：CCCN(CCC)C(=O)c1cccc(C(=O)OC)c1
HCID182776

Benzoic acid, 3-((dipropylamino)carbonyl)-, methyl ester

C15H21NO3

结构：COC(=O)c1cccc(C(=O)O)c1
HCID601880

3-(Methoxycarbonyl)benzoic acid

C9H8O4

结构：CC(C)(C)OC(=O)N1C[C@H](O)C[C@@H]1C(=O)O
HCID688616

(4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-D-proline

C10H17NO5

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

PRODUCTS

生成物

1
结构：CCCN(CCC)C(=O)c1cccc(C(=O)O)c1
HCID182769

Benzoic acid, 3-((dipropylamino)carbonyl)-

C14H19NO3

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Step E (1): Methyl 3-(dipropylcarbamoyl)benzoate. To a solution of 3-(methoxycarbonyl)benzoic acid (6.7 g, 37.2 mmol) in DMF (60 mL) was added HATU (17.0 g, 44.7 mmol) and dipropylamine (9.4 g, 93 mmol) and the reaction mixture was stirred at rt overnight. Ethyl acetate (600 mL) was added and the mixture was washed with H2O, dried and concentrated to give the title compound was used in the next step without purification.

WORKUP

后处理

  1. washthe mixture was washed with H2O
  2. customdried
  3. concentrationconcentrated