Hydrochloric Acid → 2'-Chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran]
Reaction equation
[CH:29]([OH:30])([CH3:31])[CH3:32].[Cl:2][c:3]1[cH:4][c:5]2[c:6]([s:7]1)[C:8]1([CH2:9][CH2:10][N:11]([C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:12][CH2:13]1)[O:21][CH2:22][C:23]2([F:24])[F:25].[ClH:1].[Na+:28].[OH-:27].[OH2:26]>>[Cl:2][c:3]1[cH:4][c:5]2[c:6]([s:7]1)[C:8]1([CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)[O:21][CH2:22][C:23]2([F:24])[F:25]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-e5a44841f8da495eb3040b5db4919eea
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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