Water → HCID 67048184, compound

HRID 2094331Notes

Reaction equation

HRID 2094331 reaction equation
[C:1]([NH:8][CH:9]([C:14]1[CH:18]=[CH:17][N:16]([CH3:19])[N:15]=1)[C:10]([O:12]C)=[O:11])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].O.[OH-].[Li+]>C1COCC1>[C:1]([NH:8][CH:9]([C:14]1[CH:18]=[CH:17][N:16]([CH3:19])[N:15]=1)[C:10]([OH:12])=[O:11])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 67049576HCID 67049576, compound

Product 1

HCID 67048184HCID 67048184, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.16 g (4.31 mmol) methyl N-Boc-2-amino-2-(1-methyl-pyrazol-3-yl)-acetate in 16 ml THF are combined with 10 ml of water and 10 ml of 1-molar lithium hydroxide solution are added. After stirring at ambient temperature for 2 h the mixture is evaporated down i. vac., the residue is combined with water, filtered and the filtrate is adjusted to pH 5 with potassium hydrogen sulphate solution. After total evaporation i. vac. the residue is treated with dichloromethane and a little ethanol, suction filtered and the filtrate is evaporated down completely i. vac.

Workup

  1. additionare added
  2. customis evaporated down i
  3. filtrationfiltered
  4. additionthe residue is treated with dichloromethane
  5. filtrationa little ethanol, suction filtered
  6. customthe filtrate is evaporated down completely i

Sources & evidence

ORD record
ord-eab1cb5979b140ab8fd968a35cff28bf
Source dataset
uspto-grants-2013_05
Patent number
US08445525B2

Reaction notes

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