HRID2094537

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10009

3-Pyridinamine

C5H6N2

HCID94429

Triphosgene

C3Cl6O3

结构：Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1

HCID67021644

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(-c2nc(N3CCOCC3)nc(N3C4CCC3COC4)n2)cc1)Nc1cccnc1

HCID52941479

N-[4-[4-(4-Morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl]-N′-3-pyridinylurea

C25H28N8O3

收率 50.5%

PROCEDURE

实验过程

Following the procedure described in example 34, reaction of 4-[4-morpholin-4-yl-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]aniline (22 mg, 0.06 mmol) (22 mg, 0.06 mmol, triphosgene (18 mg, 0.06 mmol) and 3-aminopyridine (17 mg, 0.18 mmol) gave the title compound as off-white solid (1TFA salt, 14.8 mg, 41% yield). MS (ESI) m/z 489.5.