Borane → 2-(3-Iodophenyl)ethanol

HRID 2095327Notes

Reaction equation

HRID 2095327 reaction equation
B.[I:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10](O)=[O:11])[CH:6]=[CH:7][CH:8]=1>C1COCC1>[I:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][OH:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 6331BoraneHCID 38702203-Iodophenylacetic acid

Product 1

HCID 151698502-(3-Iodophenyl)ethanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-(3-Iodophenyl)ethanol was prepared by borane reduction of 3-iodophenylacetic acid in THF in a similar manner as outlined in Example 17, and additionally purified by CC on SiO2 with EtOAc/hexane 2:3.

Workup

  1. customadditionally purified by CC on SiO2 with EtOAc/hexane 2:3

Sources & evidence

ORD record
ord-f644374cd3e04b7e9d5ac825785c44ae
Source dataset
uspto-grants-2013_05
Patent number
US08445684B2

Reaction notes

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