Triethylamine → HCID 58232203, compound

HRID 2095548Notes

Reaction equation

HRID 2095548 reaction equation
Cl.[OH:2][CH2:3][CH2:4][C@@H:5]([N:11]1[C:17](=[O:18])[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)[C:6]([N:8]([CH3:10])[CH3:9])=[O:7].[Cl:19][C:20]1[CH:21]=[C:22]([CH:28]=[CH:29][CH:30]=1)/[CH:23]=[CH:24]/[C:25](O)=[O:26].C(N(CC)CC)C>>[Cl:19][C:20]1[CH:21]=[C:22](/[CH:23]=[CH:24]/[C:25]([N:14]2[CH2:15][CH2:16][C:17](=[O:18])[N:11]([C@H:5]([CH2:4][CH2:3][OH:2])[C:6]([N:8]([CH3:10])[CH3:9])=[O:7])[CH2:12][CH2:13]2)=[O:26])[CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 7352502-Propenoic acid, 3-(3-chlorophenyl)-HCID 67074641HCID 67074641, compound

Product 1

HCID 58232203HCID 58232203, compoundYield 72%

Procedure

In analogy to the procedure described in example 1, (R)-4-hydroxy-N,N-dimethyl-2-(7-oxo-[1,4]diazepan-1-yl)-butyramide hydrochloride and (E)-3-chlorocinnamic acid with 1.1 eq. of triethylamine gave the titled compound in 72% yield as white foam. MS: 408.1 (MH+, 1Cl).

Sources & evidence

ORD record
ord-726497e2df8d4ccfaead48f535e36581
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

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