HCID 66783278, compound → Hydrochloric Acid

HRID 2095552Notes

Reaction equation

HRID 2095552 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20](O)=[O:21])[C:14](=[O:23])[C@@H:13]2[CH3:24])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:25][C@@H:26]1[CH2:31][NH:30][CH2:29][C@@H:28]([OH:32])[CH2:27]1>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]([N:30]3[CH2:31][C@@H:26]([CH3:25])[CH2:27][C@H:28]([OH:32])[CH2:29]3)=[O:21])[C:14](=[O:23])[C@@H:13]2[CH3:24])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 66783278HCID 66783278, compoundHCID 67074220HCID 67074220, compound2×

Product 2

HCID 313Hydrochloric AcidHCID 67074419HCID 67074419, compound

Procedure

In analogy to the procedure described in Example 15, 3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid (intermediate 12) and 1.1 eq. (3S,5S)-5-methyl-piperidin-3-ol; hydrochloride (intermediate 4) gave the titled compound in 84% yield as off-white solid. MS: 471.3 (MH+, 2Cl).

Sources & evidence

ORD record
ord-d934f722c4ff45d7a0a36924db49f837
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

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