HCID 66783210, compound → Hydrochloric Acid

HRID 2095553Notes

Reaction equation

HRID 2095553 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]([OH:22])=O)[C:14](=[O:23])[C@@H:13]2[CH3:24])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:25][C@H:26]1[CH2:31][CH2:30][NH:29][CH2:28][C@H:27]1[OH:32]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][CH2:19][C:20]([N:29]3[CH2:30][CH2:31][C@H:26]([CH3:25])[C@H:27]([OH:32])[CH2:28]3)=[O:22])[C:14](=[O:23])[C@@H:13]2[CH3:24])=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 66783210HCID 66783210, compoundHCID 67074220HCID 67074220, compound2×

Product 2

HCID 313Hydrochloric AcidHCID 58232151HCID 58232151, compound

Procedure

In analogy to the procedure described in Example 15, 3-[(S)-4-(3,4-dichloro-phenylcarbamoyl)-3-methyl-2-oxo-piperazin-1-yl]-propionic acid (intermediate 12) and 1.1 eq. (3S,4S)-4-methyl-piperidin-3-ol; hydrochloride (intermediate 3) gave the titled compound in 84% yield as off-white solid. MS: 471.3 (MH+, 2Cl).

Sources & evidence

ORD record
ord-a8d09c1b4ac84cf29443a8e02c8cdac8
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

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