HCID 67074686, compound → Hydrochloric Acid

HRID 2095593Notes

Reaction equation

HRID 2095593 reaction equation
[C:1]([O:5][C:6](=[O:24])[CH2:7][CH2:8][N:9]([C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[C:15]([Cl:23])[CH:14]=1)[CH2:10][CH:11]=O)([CH3:4])([CH3:3])[CH3:2].[CH3:25][O:26][C:27](=[O:43])[C@@H:28]([NH2:42])[CH2:29][CH2:30][C:31]([N:33]1[CH2:40][CH2:39][C:36]2([CH2:38][CH2:37]2)[C@H:35]([OH:41])[CH2:34]1)=[O:32]>>[ClH:23].[CH3:25][O:26][C:27](=[O:43])[C@@H:28]([NH:42][CH2:11][CH2:10][N:9]([CH2:8][CH2:7][C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:24])[C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:20])([F:22])[F:21])=[C:15]([Cl:23])[CH:14]=1)[CH2:29][CH2:30][C:31]([N:33]1[CH2:40][CH2:39][C:36]2([CH2:37][CH2:38]2)[C@H:35]([OH:41])[CH2:34]1)=[O:32]

Participants

4

Reactant 2

HCID 67074686HCID 67074686, compoundHCID 86652697HCID 86652697, compound

Product 2

HCID 313Hydrochloric AcidHCID 67075088HCID 67075088, compound

Procedure

In analogy to the procedure described for example 14C, 3-[(3-chloro-4-trifluoromethyl-phenyl)-(2-oxo-ethyl)-amino]-propionic acid tert-butyl ester and (S)-2-amino-5-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-5-oxo-pentanoic acid methyl ester; compound with HCl (intermediate 41) gave the title compound in 52% yield as light yellow foam. MS: 620.27 (MH+, Cl).

Sources & evidence

ORD record
ord-3498b7f450954d2797604c41378d1aa9
Source dataset
uspto-grants-2013_05
Patent number
US08445674B2

Reaction notes

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