Tetrahydrofuran → HCID 58158612, compound

HRID 2095815Notes

Reaction equation

HRID 2095815 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12](=[O:13])[C:11]([C:14]([O:16]CC)=[O:15])=[CH:10][N:9]1[CH3:19].O1CCCC1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12](=[O:13])[C:11]([C:14]([OH:16])=[O:15])=[CH:10][N:9]1[CH3:19]

Participants

5

Reactant 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 58158541HCID 58158541, compound

Product 1

HCID 58158612HCID 58158612, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as in Reference Example 65 and using ethyl 2-(2-chlorophenyl)-1-methyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (2.8 g, 9.9 mmol), tetrahydrofuran (6 mL), methanol (5 mL) and 4N aqueous sodium hydroxide solution (8 mL) as starting materials, the title compound (2.3 g, 91%) was obtained as a white solid.

Sources & evidence

ORD record
ord-e59c68ca752041df8ce6b18d34c8fb8d
Source dataset
uspto-grants-2013_05
Patent number
US08445509B2

Reaction notes

Loading…