Ethyl Acetate → Methyl Acetate

HRID 2096128Notes

Reaction equation

HRID 2096128 reaction equation
[C:1]([O:5]C)([CH3:4])([CH3:3])C.[C:7]([O:10][CH2:11][CH3:12])(=[O:9])[CH3:8]>C(OCCCC)(=O)C>[C:7]([O:10][CH3:11])(=[O:9])[CH3:8].[C:7]([O:10][CH:11]([CH3:1])[CH3:12])(=[O:9])[CH3:8].[CH2:4]([OH:9])[C@@H:1]([OH:5])[CH3:3]

Participants

6

Reactant 2

HCID 8857Ethyl AcetateHCID 15413tert-Butyl methyl ether

Product 3

HCID 6584Methyl AcetateHCID 7915Isopropyl AcetateHCID 439846(S)-propane-1,2-diol

Reagents, catalysts & solvents 1

HCID 31272Butyl AcetateSolvent

Procedure

The reaction mixture containing compound I is treated with an organic solvent such as methyl tert-butyl ether or an alkyl acetate such as ethyl acetate, methyl acetate, isopropyl acetate, or butyl acetate, and (S)-propylene glycol, optionally adding seeds of compound Ia to the mixture, to provide compound Ia.

Sources & evidence

ORD record
ord-b2493681fe8641c6886805f0f5407943
Source dataset
uspto-grants-2013_05
Patent number
US08450286B2

Reaction notes

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