Trifluoroacetic acid → HCID 86642252, compound

HRID 2096162Notes

Reaction equation

HRID 2096162 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:11][N:10]([CH:12]2[CH2:17][CH2:16][C:15]([OH:26])([C:18]3[CH:19]=[N:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=3)[CH2:14][CH2:13]2)[CH2:9]1)(C)(C)C.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]>C(Cl)Cl>[OH:34][C:28]([C:30]([F:33])([F:32])[F:31])=[O:29].[NH2:7][CH:8]1[CH2:9][N:10]([CH:12]2[CH2:13][CH2:14][C:15]([C:18]3[CH:19]=[N:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=3)([OH:26])[CH2:16][CH2:17]2)[CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59361626HCID 59361626, compound

Product 1

HCID 86642252HCID 86642252, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

{1-[4-Hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-azetidin-3-yl}-carbamic acid tert-butyl ester (less polar isomer from Step A, 5.50 g, 14.6 mmol) in DCM (10 mL) and TFA (10 mL) at room temperature was stirred for 2 hours. The solvent was removed and dried under vacuum to give the title compound as colorless oil.

Workup

  1. customThe solvent was removed
  2. customdried under vacuum

Sources & evidence

ORD record
ord-976ea85e2b3646dc98a3963c56d339f3
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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