1,4-Dioxaspiro[4.5]decan-8-one → 8-(1-Methyl-1H-imidazol-2-yl)-1,4-dioxa-spiro[4.5]decan-8-ol

HRID 2096180Notes

Reaction equation

HRID 2096180 reaction equation
Br[C:2]1[N:3]([CH3:7])[CH:4]=[CH:5][N:6]=1.[O:8]1[C:12]2([CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]2)[O:11][CH2:10][CH2:9]1>C1COCC1>[CH3:7][N:3]1[CH:4]=[CH:5][N:6]=[C:2]1[C:15]1([OH:18])[CH2:16][CH2:17][C:12]2([O:11][CH2:10][CH2:9][O:8]2)[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 27732622-Bromo-1-methyl-1H-imidazole

Product 1

HCID 593615828-(1-Methyl-1H-imidazol-2-yl)-1,4-dioxa-spiro[4.5]decan-8-ol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared as a white solid from 2-bromo-1-methyl-1H-imidazole (Aldrich) and 1,4-dioxa-spiro[4.5]decan-8-one in THF using the procedure described in Step A of Example 1.

Sources & evidence

ORD record
ord-4925b5b0b958480383dc6babf696d132
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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