Trifluoroacetic acid → N-(Azetidin-3-ylcarbamoylmethyl)-3,5-bis-trifluoromethyl-benzamide TFA salt

HRID 2096234Notes

Reaction equation

HRID 2096234 reaction equation
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C(OC([N:15]1[CH2:18][CH:17]([NH:19][C:20](=[O:39])[CH2:21][NH:22][C:23](=[O:38])[C:24]2[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[C:26]([C:34]([F:37])([F:36])[F:35])[CH:25]=2)[CH2:16]1)=O)(C)(C)C>>[OH:7][C:1]([C:3]([F:6])([F:5])[F:4])=[O:2].[NH:15]1[CH2:18][CH:17]([NH:19][C:20]([CH2:21][NH:22][C:23](=[O:38])[C:24]2[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[C:26]([C:34]([F:35])([F:37])[F:36])[CH:25]=2)=[O:39])[CH2:16]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59361639HCID 59361639, compound

Product 1

HCID 86642254N-(Azetidin-3-ylcarbamoylmethyl)-3,5-bis-trifluoromethyl-benzamide TFA salt

Procedure

The title compound was prepared as colorless oil from TFA de-protection of 3-[2-(3,5-bis-trifluoromethyl-benzoylamino)-acetylamino]-azetidine-1-carboxylic acid tert-butylester, as prepared in the previous step, using the procedure described in Step D of Example 1.

Workup

  1. customas prepared in the previous step

Sources & evidence

ORD record
ord-2c928749b89946e9bca6233df85baceb
Source dataset
uspto-grants-2013_05
Patent number
US08450304B2

Reaction notes

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