反应详情

144 mg (0.500 mmol) 6-(6-chloropyrimidine-4-carbonyl)-4-methyl-3H-benzoxazol-2-one, 108 mg (0.500 mmol) 1′H-spiro[piperidin-4,4′-quinazolin]-2′(3′H)-one and 0.174 mL (1.00 mmol) DIPEA were combined in 5.0 mL DMF and stirred overnight at RT. The reaction mixture was purified by preparative HPLC, the fractions containing the product were combined and the organic solvent was eliminated i.vac. The aqueous phase was neutralised by the addition of 4N aqueous NaOH solution. The product precipitated as a solid was filtered off, washed with water and dried.

1. customThe reaction mixture was purified by preparative HPLC
2. additionthe fractions containing the product
3. additionThe aqueous phase was neutralised by the addition of 4N aqueous NaOH solution
4. customThe product precipitated as a solid
5. filtrationwas filtered off
6. washwashed with water
7. customdried