反应详情

To a mixture of 6-bromo-2-phenyl-2′-thioxospiro[chroman-4,4′-imidazolidin]-5′-one (250 mg, 0.64 mmol) and K2CO3 (356 mg, 2.6 mmol) in CH3CN (8 mL) was added EtI (402 mg, 2.6 mmol). The reaction mixture was refluxed for 2 h. The mixture was filtered, and the filtrate was concentrated to give a residue, which was purified by preparative TLC to give 6-bromo-1′-ethyl-2′-(ethylthio)-2-phenylspiro[chroman-4,4′-imidazol]-5′(1′H)-one (195 mg, 69%).

1. temperatureThe reaction mixture was refluxed for 2 h
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated
4. customto give a residue, which
5. customwas purified by preparative TLC