反应详情

Iodomethane (2.41 g) was added to a suspension of 5-bromo-1,3-dihydro-benzoimidazol-2-one (1.65 g) and potassium tert-butoxide (1.91 g) in DMA (20 ml). The mixture was stirred overnight at room temperature. The mixture was poured to 2.5N aqueous HCl (80 ml) and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and then concentrated in vacuo. Heptane (50 ml) was added to the residue and the mixture was filtered. The residue was washed with diethyl ether and dried in vacuo to give the title compound (1.1 g) as a light brown solid. MS (m/e)=241.1 [M+H+].

1. extractionextracted with EtOAc
2. dry with materialThe combined organic layers were dried over Na2SO4
3. concentrationconcentrated in vacuo
4. additionHeptane (50 ml) was added to the residue
5. filtrationthe mixture was filtered
6. washThe residue was washed with diethyl ether
7. customdried in vacuo