Hydrochloric Acid → HCID 66905887, compound

HRID 2097231Notes

Reaction equation

HRID 2097231 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12](=[O:29])[CH2:13][CH2:14][CH:15]([NH:21]C(=O)OC(C)(C)C)[C:16]3[CH:20]=[CH:19][S:18][CH:17]=3)=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[ClH:30]>C(Cl)Cl>[ClH:30].[ClH:30].[NH2:21][CH:15]([C:16]1[CH:20]=[CH:19][S:18][CH:17]=1)[CH2:14][CH2:13][C:12]([NH:11][C:7]1[CH:6]=[C:5]2[C:10](=[CH:9][CH:8]=1)[CH:1]=[N:2][CH:3]=[CH:4]2)=[O:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59161742HCID 59161742, compound

Product 1

HCID 66905887HCID 66905887, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To tert-butyl 4-(isoquinolin-6-ylamino)-4-oxo-1-(thiophen-3-yl)butylcarbamate (E73E) in CH2Cl2 is added HCl (4N in dioxane), and the solution is stirred for 8 hours. The solvents are evaporated to give 4-amino-N-(isoquinolin-6-yl)-4-(thiophen-3-yl)butanamide dihydrochloride (E73).

Workup

  1. customThe solvents are evaporated

Sources & evidence

ORD record
ord-27b39a418de74cefaab04d6a237b5d18
Source dataset
uspto-grants-2013_05
Patent number
US08450344B2

Reaction notes

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