1-Naphthaleneacetic Acid → Methyl 3-(2-(naphthalen-1-yl)acetamido)thiophene-2-carboxylate

HRID 2098165Notes

Reaction equation

HRID 2098165 reaction equation
[NH2:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([O:9][CH3:10])=[O:8].[C:11]1([CH2:21][C:22](O)=[O:23])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH:12]=1>>[C:11]1([CH2:21][C:22]([NH:1][C:2]2[CH:6]=[CH:5][S:4][C:3]=2[C:7]([O:9][CH3:10])=[O:8])=[O:23])[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 68621-Naphthaleneacetic AcidHCID 89652Methyl 3-amino-2-thiophenecarboxylate

Product 1

HCID 25660569Methyl 3-(2-(naphthalen-1-yl)acetamido)thiophene-2-carboxylate

Procedure

Methyl 3-(2-(naphthalen-1-yl)acetamido)thiophene-2-carboxylate was prepared from methyl 3-aminothiophene-2-carboxylate (4.30 g, 27.3 mmol) and 2-(naphthalen-1-yl)acetic acid (3.10 g, 27.3 mmol) according to protocol A. Retention time (min)=8.738, method [7], MS (ESI) 326.1 (M+H).

Sources & evidence

ORD record
ord-22b0eb4bac4a4c85baf38fe371815ca6
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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