Diisopropylethylamine → HCID 86649428, compound

HRID 2098167Notes

Reaction equation

HRID 2098167 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:11][OH:12].Cl.C(N(C(C)C)CC)(C)C>C(O)C>[N:5]1[C:4]2[S:8][CH:9]=[CH:10][C:3]=2[C:2]([NH:11][OH:12])=[N:7][CH:6]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 443297Hydroxyamine hydrochlorideHCID 7366184-Chlorothieno[2,3-d]pyrimidine

Product 1

HCID 86649428HCID 86649428, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-chlorothieno[2,3-d]pyrimidine (340 mg, 1.99 mmol), hydroxylamine-hydrogen chloride (550 mg, 7.91 mmol), and diisopropylethylamine (1 ml) in absolute ethanol (5 ml) was placed into a preheated oil bath at 75° C. After stirring for 6 h, the solution was concentrated under reduced pressure.

Workup

  1. concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-de0af972b51a4328a96083e12fbe7c6d
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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