Hydrochloric Acid → Methyl 5-amino-1,3-thiazole-4-carboxylate

HRID 2098170Notes

Reaction equation

HRID 2098170 reaction equation
Cl.C1(C(=[N:15][C:16]2[S:20][CH:19]=[N:18][C:17]=2[C:21]([O:23][CH3:24])=[O:22])C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[NH2:15][C:16]1[S:20][CH:19]=[N:18][C:17]=1[C:21]([O:23][CH3:24])=[O:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86649429HCID 86649429, compound

Product 1

HCID 53408092Methyl 5-amino-1,3-thiazole-4-carboxylateYield 71.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Aqueous 3N HCl (1 mL) was added to a solution of methyl 5-(diphenylmethyleneamino)thiazole-4-carboxylate (1.22 g, 3.81 mmol) in THF (5 mL). The reaction mixture was stirred for 1 h and the white solid which had formed was isolated by filtration to give methyl 5-aminothiazole-4-carboxylate (0.527 g, 2.72 mmol, 71%). Retention time (min)=0.422, method [7], MS (ESI) 159.0 (M+H).

Workup

  1. customthe white solid which had formed
  2. customwas isolated by filtration

Sources & evidence

ORD record
ord-f771b77617754ec398c019c9243a9d75
Source dataset
uspto-grants-2013_05
Patent number
US08450363B2

Reaction notes

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