Methylamine → HCID 178482580, compound

HRID 2098698Notes

Reaction equation

HRID 2098698 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.[CH3:19][NH2:20]>CO>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9](/[CH:11]=[N:20]/[CH3:19])=[CH:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 178482580HCID 178482580, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde 10 (1.0 g) in methanol under nitrogen was added methylamine solution (11.79 g methylamine in 50 ml methanol) (1.39 ml). The reaction mixture was stirred at room temperature overnight. The solvents were then removed in vacuo to yield [1-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)-meth-(E)-ylidene]-methyl-amine.

Workup

  1. customThe solvents were then removed in vacuo

Sources & evidence

ORD record
ord-c825cfa2d80e49c099d853db601b0220
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Reaction notes

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