2-Methoxyethylamine → N-(2-methoxyethyl)methanesulfonamide

HRID 2098716Notes

Reaction equation

HRID 2098716 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].C(N(CC)CC)C.[CH3:13][S:14](Cl)(=[O:16])=[O:15]>ClCCl>[CH3:1][O:2][CH2:3][CH2:4][NH:5][S:14]([CH3:13])(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 80182-MethoxyethylamineHCID 8471TriethylamineHCID 31297Methanesulfonyl chloride

Product 1

HCID 3522477N-(2-methoxyethyl)methanesulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 2-methoxyethylamine (0.58 ml) in dichloromethane (10 ml) was added triethylamine (1.0 ml) and methanesulphonyl chloride (0.51 ml). The mixture was stirred at room temperature overnight. The solvents were removed in vacuo to give a crude product which was purified by flash chromatography to give N-(2-Methoxy-ethyl)-methanesulfonamide (0.74 g).

Workup

  1. customThe solvents were removed in vacuo
  2. customto give a crude product which
  3. customwas purified by flash chromatography

Sources & evidence

ORD record
ord-5c533c63910049a7973a3ff144baf9cf
Source dataset
uspto-grants-2013_05
Patent number
US08450315B2

Reaction notes

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