Sodium Iodide → 3-iodo-N,N-dimethylpropane-1-sulfonamide
Reaction equation
[CH3:1][N:2]([CH3:10])[S:3]([CH2:6][CH2:7][CH2:8]Cl)(=[O:5])=[O:4].[I-:11].[Na+]>CC(=O)CC>[CH3:1][N:2]([CH3:10])[S:3]([CH2:6][CH2:7][CH2:8][I:11])(=[O:5])=[O:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
A mixture of 3-chloro-propane-1-sulfonic acid dimethylamide (1.06 g) and sodium iodide (2.57 g) in 2-butanone (20 mL) was heated at 80° C. for 16 h. After cooling to room temperature the solvent was reduced in vacuo. The residue was partitioned between ethyl acetate (20 mL) and water (20 mL). The organic layer was dried (MgSO4) and reduced in vacuo to give 3-iodo-propane-1-sulfonic acid dimethylamide as a yellow solid.
Workup
- temperatureAfter cooling to room temperature the solvent
- customThe residue was partitioned between ethyl acetate (20 mL) and water (20 mL)
- dry with materialThe organic layer was dried (MgSO4)
Sources & evidence
- ORD record
- ord-1e3754eba3d04522949c2e122ae15ca4
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08450315B2
Reaction notes
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