Hydrochloric Acid → 1-[2-Chloro-4-(trifluoromethoxy)phenyl]methanamine--hydrogen chloride (1/1)

HRID 2099312Notes

Reaction equation

HRID 2099312 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([O:10][C:11]([F:14])([F:13])[F:12])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:9]=[C:8]([O:10][C:11]([F:12])([F:13])[F:14])[CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 668610192-Chloro-4-(trifluoromethoxy)benzonitrile

Product 1

HCID 668615221-[2-Chloro-4-(trifluoromethoxy)phenyl]methanamine--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The preparation takes place in analogy to Example 6A from the compound from Example 3A with subsequent treatment with 4N hydrochloric acid in dioxane.

Sources & evidence

ORD record
ord-403702ddbcae4f0c98f5bedeae697e1c
Source dataset
uspto-grants-2009_08
Patent number
US07569563B2

Reaction notes

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