Oxalyl chloride → 2,2-diphenylpropanoyl Chloride

HRID 2099335Notes

Reaction equation

HRID 2099335 reaction equation
C(Cl)(=O)C([Cl:4])=O.[C:7]1([C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[C:14](O)=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CN(C)C=O.ClCCl>[C:7]1([C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([CH3:17])[C:14]([Cl:4])=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 796762,2-Diphenylpropionic acid

Product 1

HCID 114479422,2-diphenylpropanoyl Chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
50 °C

Procedure

52.08 g (0.33 mol) of oxalyl chloride are slowly added dropwise to a suspension of 25.0 g (0.11 mol) of 2,2-diphenylpropionic acid, 100 mL of dichloromethane, and 4 drops of dimethylformamide at 20° C. The mixture is stirred for 1 hour at 20° C. and 0.5 hours at 50° C. The solvent is distilled off and the residue remaining is used in the next step without any further purification.

Workup

  1. distillationThe solvent is distilled off
  2. customthe residue remaining is used in the next step without any further purification

Sources & evidence

ORD record
ord-b78019ca6727486db87996adc2c773ae
Source dataset
uspto-grants-2009_08
Patent number
US07569581B2

Reaction notes

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