反应详情

A mixture of 4-chlorobenzaldehyde (2.0 g, 10.2 mmol), 20% hydrochloric acid (4 mL) was added to an aminoguanidine bicarbonate (1.39 g, 10.2 mmol) aqueous solution, and heated to reflux for 4 h. A solution of 40% aqueous potassium hydroxide (7 mL) was added dropwise, the mixture was heated at reflux for 10 min and the precipitate formed. The precipitate was filtered, washed with water, and recrystallized from ethanol to give 2-[(E)-1-(4-chlorophenyl)methylidene]-1-hydrazinecarboximidamide (1.77 g, 88%) as a yellow solid.

1. temperatureheated
2. temperatureto reflux for 4 h
3. temperaturethe mixture was heated
4. temperatureat reflux for 10 min
5. customthe precipitate formed
6. filtrationThe precipitate was filtered
7. washwashed with water
8. customrecrystallized from ethanol