HRID2099782

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID87836

1-(Bromomethyl)-4-(1,1-dimethylethyl)benzene

C11H15Br

结构：Cc1cc(CC(NC(=O)OC(C)(C)C)c2ncc[nH]2)cc2cn(COCC[Si](C)(C)C)nc12

HCID57794668

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(CC(NC(=O)OC(C)(C)C)c2nccn2Cc2ccc(C(C)(C)C)cc2)cc2cn(COCC[Si](C)(C)C)nc12

HCID57794722

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

(tert-Butyl-1-(1H-imidazol-2-yl)-2-(7-methyl-2-[{2-[trimethylsilyl]ethoxy}methyl]-2H-indazol-5-yl)ethylcarbamate (40 mg, 0.085 mmol), 4-(tert-Butyl)-benzyl bromide (16.3 μL, 0.089 mmol, 1.05 equiv), and potassium carbonate (23.5 mg, 0.17 mmol) were combined in dimethylformamide (1.0 mL). After stirring at room temperature for 16 h, the solvents were removed and the residue purified by column chromatography to afford 36.0 mg (79%). Mass spec.: 618.6 (MH)+.

WORKUP

后处理

customthe solvents were removed
customthe residue purified by column chromatography
customto afford 36.0 mg (79%)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-25f18e79b14d49cb8340e6b1bc973d90
来源数据集: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07569578B2
来源说明: uspto-grants-2009_08

反应 SMILES

[C:1]([O:5][C:6](=[O:33])[NH:7][CH:8]([C:28]1[NH:29][CH:30]=[CH:31][N:32]=1)[CH2:9][C:10]1[CH:18]=[C:17]([CH3:19])[C:16]2[C:12](=[CH:13][N:14]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[N:15]=2)[CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[C:34]([C:38]1[CH:45]=[CH:44][C:41]([CH2:42]Br)=[CH:40][CH:39]=1)([CH3:37])([CH3:36])[CH3:35].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:34]([C:38]1[CH:39]=[CH:40][C:41]([CH2:42][N:32]2[CH:31]=[CH:30][N:29]=[C:28]2[CH:8]([NH:7][C:6](=[O:33])[O:5][C:1]([CH3:4])([CH3:2])[CH3:3])[CH2:9][C:10]2[CH:18]=[C:17]([CH3:19])[C:16]3[C:12](=[CH:13][N:14]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:25])([CH3:27])[CH3:26])[N:15]=3)[CH:11]=2)=[CH:44][CH:45]=1)([CH3:37])([CH3:35])[CH3:36]