反应详情

温度

40 °C

2-(Benzyloxycarbonyl)-3-(7-methyl-1H-indazol-5-yl)propanoic acid (0.2 g, 0.57 mmol), hydroxybenzotriazole (84 mg, 0.62 mmol), 1-(3-dimethyl aminopropyl)-3-ethyl carbodiimide hydrochloride (0.12 g, 0.62 mmol), and 2,2-dimethylpropan-1-amine (74 μL, 0.62 mmol) were combined in ethyl acetate (6.0 mL). To this solution was added triethylamine (0.24 mL, 1.7 mmol) and the reaction mixture stirred at 40° C. for 2 h. After cooling to room temperature, the mixture was diluted with ethyl acetate, washed with 5% citric acid (2×), brine (2×), dried over sodium sulfate, and concentrated to afford 0.21 g (88%). Mass spec.: 423.06 (MH)+.

1. temperatureAfter cooling to room temperature
2. washwashed with 5% citric acid (2×), brine (2×)
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated
5. customto afford 0.21 g (88%)