Trifluoroacetic acid → HCID 69054704, compound

HRID 2099903Notes

Reaction equation

HRID 2099903 reaction equation
[C:1]([NH:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16](N3CC4CN(C(OC(C)(C)C)=O)CC4C3)[N:15]([CH2:33][CH:34]=[C:35]([CH3:37])[CH3:36])[C:14]=2[CH:38]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[C:40](F)(F)[C:41](O)=O>O>[CH:10]1([C:16]2[N:15]([CH2:33][CH:34]=[C:35]([CH3:36])[CH3:37])[C:14]3[CH:38]=[C:10]([NH:9][C:1](=[O:8])[C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH:11]=[CH:12][C:13]=3[N:17]=2)[C:38]2=[CH:14][NH:15][CH2:40][CH:41]2[CH2:1][NH:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57796667HCID 57796667, compound

Product 1

HCID 69054704HCID 69054704, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

10 mg (0.02 mmol) of tert-butyl 5-[6-benzoylamino-1-(3-methylbut-2-enyl)-1H-benzimidazol-2-yl]hexahydropyrrolo[3,4-c]pyrrole-2-carboxylate were dissolved in 200 μl of trifluoroacetic acid and 200 μl of water, and stirred at room temperature for 19 hours. The reaction mixture was diluted with water and freeze-dried. 10 mg (95%) of the desired product were obtained.

Workup

  1. customfreeze-dried

Sources & evidence

ORD record
ord-935edd1aee744b51b2654df0856e5533
Source dataset
uspto-grants-2009_08
Patent number
US07569700B2

Reaction notes

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