Diisopropylcarbodiimide → 2-[[3-chloro-4-[(3,4-dimethoxyphenyl)methoxy]benzoyl]amino]-N-[2-(2-methoxyphenyl)ethyl]-5-phenoxy-benzamide

HRID 2099962노트

반응식

HRID 2099962 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][C:36]=1[O:37][CH3:38])[CH2:6][O:7][C:8]1[CH:32]=[CH:31][C:11]([C:12]([NH:14][C:15]2[CH:23]=[CH:22][C:21]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:20][C:16]=2[C:17](O)=[O:18])=[O:13])=[CH:10][C:9]=1[Cl:33].C1C=CC2N(O)N=NC=2C=1.C(N=C=NC(C)C)(C)C.[CH3:58][O:59][C:60]1[CH:68]=[CH:67][CH:66]=[CH:65][C:61]=1[CH2:62][CH2:63][NH2:64]>CN(C=O)C>[Cl:33][C:9]1[CH:10]=[C:11]([CH:31]=[CH:32][C:8]=1[O:7][CH2:6][C:5]1[CH:34]=[CH:35][C:36]([O:37][CH3:38])=[C:3]([O:2][CH3:1])[CH:4]=1)[C:12]([NH:14][C:15]1[CH:23]=[CH:22][C:21]([O:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[CH:20][C:16]=1[C:17]([NH:64][CH2:63][CH2:62][C:61]1[CH:65]=[CH:66][CH:67]=[CH:68][C:60]=1[O:59][CH3:58])=[O:18])=[O:13]

참가 물질

6

반응물 4

HCID 12734DiisopropylcarbodiimideHCID 748962-MethoxyphenethylamineHCID 757711-HydroxybenzotriazoleHCID 577968912-(4-(3,4-Dimethoxybenzyloxy)-3-chlorobenzamido)-5-phenoxybenzoic acid

생성물 1

HCID 577968852-[[3-chloro-4-[(3,4-dimethoxyphenyl)methoxy]benzoyl]amino]-N-[2-(2-methoxyphenyl)ethyl]-5-phenoxy-benzamide수율 73%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 1D (30 mg, 0.056 mmol) in DMF (2 mL) was treated with HOBt (15 mg, 0.11 mmol) and diisopropylcarbodiimide (13 μL, 0.084 mmol) at room temperature. The reaction was stirred for one hour then 2-methoxyphenethylamine was added. The resulting solution was stirred for three hours, concentrated and purified by chromatography (SiO2, 0.5% MeOH in CH2Cl2) to afford 1E (27 mg, 73%).

후처리

  1. stirringThe resulting solution was stirred for three hours
  2. concentrationconcentrated
  3. custompurified by chromatography (SiO2, 0.5% MeOH in CH2Cl2)

출처 및 근거

ORD 기록
ord-86463613588b44b4bbd26a2655d0952a
출처 데이터셋
uspto-grants-2009_08
특허 번호
US07569725B2

반응 노트

불러오는 중…