Hydrochloric Acid → 2-(3-Chloro-4-methoxybenzamido)-5-phenoxybenzoic acid

HRID 2099975ノート

反応式

HRID 2099975 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:5]([NH:7][C:8]1[CH:18]=[CH:17][C:16]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:15][C:9]=1[C:10]([O:12]CC)=[O:11])=[O:6].O.[Li+].[OH-].Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:5]([NH:7][C:8]1[CH:18]=[CH:17][C:16]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[CH:15][C:9]=1[C:10]([OH:12])=[O:11])=[O:6]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 57796890Ethyl 2-(3-chloro-4-methoxybenzamido)-5-phenoxybenzoate

生成物 1

HCID 577968992-(3-Chloro-4-methoxybenzamido)-5-phenoxybenzoic acid収率 76%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 43C (60 mg, 0.14 mmol) in THF (2 mL):water (1 mL) at 0° C. was treated with a 1 M solution of LiOH (0.17 mmol). The reaction was warmed to room temperature and stirred for 30 minutes. The solution was neutralized with 1 N HCl and extracted with EtOAc. The combined organic layers were dried (Na2SO4), filtered and concentrated to afford 43D (42 mg, 76%).

後処理

  1. extractionextracted with EtOAc
  2. dry with materialThe combined organic layers were dried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-1f91a27ec15a4465876f168874043308
出典データセット
uspto-grants-2009_08
特許番号
US07569725B2

反応ノート

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