反应详情

To 146 mg (1 mmol) of 5-phenyltetrazole and 75 mg (1 mmol) of chloroacetonitrile was added three mL of dimethyl formamide. The resulting solution was stirred, then 158 mg (1 mmol) of potassium carbonate was added and the mixture was further stirred at room temperature for 18 hours. Twenty-five mL of water was then added and the mixture was extracted twice with 25 mL of ethyl acetate. Evaporation of the extracts left the crude product, which was purified by silica gel chromatography, leaving an oil that was pure by NMR.

1. stirringthe mixture was further stirred at room temperature for 18 hours
2. extractionthe mixture was extracted twice with 25 mL of ethyl acetate
3. customEvaporation of the extracts
4. waitleft the crude product, which
5. customwas purified by silica gel chromatography
6. customleaving an oil that